Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dichlorobenzoic acid → 5-Chloro-2-[2-methyl-3-(trifluoromethyl)anilino]benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dichlorobenzoic acid | HCID 5784 | — |
| 반응물 | 1-Pentanol | HCID 6276 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Trifluoromethyl toluidine | HCID 2735932 | — |
| 촉매 | Copper | HCID 23978 | — |
| 생성물 | 5-Chloro-2-[2-methyl-3-(trifluoromethyl)anilino]benzoic acid | HCID 45117703 | — |
반응 단계
To a solution of 25 g. of 2,5-dichlorobenzoic acid in 125 ml. of n-pentyl alcohol add 4.8 g. of sodium hydroxide pellets, 25 g. of 2-methyl-3-trifluoromethylaniline and 2 g. of copper powder. With constant stirring, reflux the reaction mixture for 18 hours. Concentrate the mixture to one half volume and dilute with water and ether. Acidify the aqueous layer to yield the product which is recrystallized from methanol, m.p. 220°-222° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04029815 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-4d4f4c4afad6436984261a6ffd258e11 |
| 출처 메모 | uspto-grants-1977_06 |