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Sodium Carbonate → cis(+/-)-4-Chloro-N-[3-ethoxy-1-(1,3-thiazol-2-yl)piperidin-4-yl]-5-ethyl-1H-imidazole-2-carboxamide

HRID 43720
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인쇄 미리보기

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HRID 43720 반응식
Cl.[Cl:2][C:3]1[N:4]=[C:5]([C:10]([NH:12][C@H:13]2[CH2:18][CH2:17][NH:16][CH2:15][C@H:14]2[O:19][CH2:20][CH3:21])=[O:11])[NH:6][C:7]=1[CH2:8][CH3:9].Br[C:23]1[S:24][CH:25]=[CH:26][N:27]=1.C(=O)([O-])[O-].[Na+].[Na+]>CN(C=O)C>[Cl:2][C:3]1[N:4]=[C:5]([C:10]([NH:12][C@H:13]2[CH2:18][CH2:17][N:16]([C:23]3[S:24][CH:25]=[CH:26][N:27]=3)[CH2:15][C@H:14]2[O:19][CH2:20][CH3:21])=[O:11])[NH:6][C:7]=1[CH2:8][CH3:9]
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참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 764302-BromothiazoleHCID 86648665cis(+/-)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride

생성물 1

HCID 86648669cis(+/-)-4-Chloro-N-[3-ethoxy-1-(1,3-thiazol-2-yl)piperidin-4-yl]-5-ethyl-1H-imidazole-2-carboxamide수율 40.2%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol), 2-bromothiazole (0.040 mL, 0.44 mmol) and sodium carbonate (157 mg, 1.48 mmol) were suspended in DMF (3 mL). The suspension was subjected to the same operation as in Example (131b) to obtain 45.8 mg of the title compound as a colorless oily substance (40%).

출처 및 근거

ORD 기록
ord-652ef77bf7a040e2be4481aa9b3f1134
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08536197B2

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