Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-[3-(1-Naphthoxy)-2-hydroxyprop-1-yl]-4-benzamidopiperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Chloro-3-(1-naphthyloxy)-2-propanol | HCID 89276 | — |
| 반응물 | N-4-Piperidylbenzamide | HCID 118120 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 1-[3-(1-Naphthoxy)-2-hydroxyprop-1-yl]-4-benzamidopiperidine | HCID 21430647 | — |
반응 단계
3-(α-Naphthoxy)-1-chloropropan-2-ol (1.18 g.) was refluxed for 16 hours in isopropyl alcohol (100 ml.) with 4-benzamidopiperidine (1.032 g.) and anhydrous potassium carbonate (1.037 g.). The mixture was filtered hot, cooled and evaporated to dryness. The gum so obtained gave the title compound as a solid on triturating in ether, m.p. 139°-141° C. (Found: C, 74.1; H, 7.1; N, 6.9. C25H28N2O3 requires C, 74.2; H, 7.0; N, 6.9%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04029801 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-8fb03f6ffe34446b84c56e7af70e3b1a |
| 출처 메모 | uspto-grants-1977_06 |