Potassium Carbonate → 1-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine

HRID 437236노트

반응식

[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:22][C:23]1[CH:24]=[C:25]([CH2:30][CH2:31]Br)[CH:26]=[CH:27][C:28]=1[Cl:29]>>[Cl:22][C:23]1[CH:24]=[C:25]([CH2:30][CH2:31][N:13]2[CH2:14][CH2:15][CH:10]([NH:9][C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:12]2)[CH:26]=[CH:27][C:28]=1[Cl:29]

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 118120N-4-Piperidylbenzamide

HCID 151493894-(2-Bromoethyl)-1,2-dichlorobenzene

생성물 1

HCID 214132531-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine수율 94.2%

반응 조건

온도: 100 °C

실험 절차

4-Benzamidopiperidine (204 mg.) and anhydrous potassium carbonate (138 mg.) were intimately ground together and added to 2-(3,4-dichlorophenyl)ethyl bromide (254 mg.). The resulting paste was heated at 100° C. for 2 hours to give a hard solid. This was broken up, washed well with water and ether and dried to give the title compound (355 mg.). Recrystallisation from ethanolic hydrogen chloride and ether gave the hydrochloride (237 mg.), m.p. 286.0° C. (Found: C, 58.2; H, 5.8; N, 6.8. C20H22Cl2N2O.HCl requires C, 58.05; H, 5.6; N, 6.8%).

후처리

customto give a hard solid
washwashed well with water and ether
customdried

출처 및 근거

ORD 기록: ord-a573edf98c094f8e8fcbc186544096e3
출처 데이터셋: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04029801

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