Sodium Carbonate → 1,3-Bis[4-(2-formylhydrazino)phenyl]thiourea

HRID 437287

반응식

HRID 437287 반응식
[C:1](=[O:4])([O-])[O-].[Na+].[Na+].C(CS[C:12](=[S:18])SCC(O)=O)(O)=O.[CH:19]([NH:21][NH:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=1)=[O:20]>O>[CH:19]([NH:21][NH:22][C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:12]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([NH:22][NH:21][CH:1]=[O:4])=[CH:24][CH:25]=2)=[S:18])=[CH:25][CH:24]=1)=[O:20]

참가 물질

5

반응물 3

HCID 10340Sodium Carbonate2회HCID 806183,5-Dithia-4-thioxo-1,7-heptanedioic acidHCID 113189Hydrazinecarboxaldehyde, 2-(4-aminophenyl)-

생성물 1

HCID 196096521,3-Bis[4-(2-formylhydrazino)phenyl]thiourea

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
95 °C

실험 절차

Sodium carbonate (2.1 g, 0.02 mole) was dissolved in water (100 ml). Bis(carboxymethyl)trithiocarbonate (4.5 g, 0.02 mole) was added portionwise with vigorous stirring. The pH of the reaction mixture was adjusted to 9.5 by the addition of sodium carbonate. The mixture was then heated to approximately 95° C. 1-Formyl-2-(4-aminophenyl)hydrazine (6.5 g, 0.043 mole) was added in one portion to the reaction mixture. Stirring was continued for five minutes. The reaction mixture was chilled, the solid was filtered off, washed thoroughly with water and dried. Yield 4.5 g (66%), m.p. 212°-214° C.

후처리

  1. temperatureThe reaction mixture was chilled
  2. filtrationthe solid was filtered off
  3. washwashed thoroughly with water
  4. customdried

출처 및 근거

ORD 기록
ord-d3838d8d3dc54476bb9561df8d3fd504
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04030925

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