Sodium Carbonate → 1,3-Bis[4-(2-benzoylhydrazino)phenyl]thiourea

HRID 437288

반응식

HRID 437288 반응식
[C:1](=[O:4])([O-])[O-].[Na+].[Na+].C(CS[C:12](=[S:18])SCC(O)=O)(O)=O.[C:19]([NH:27][NH:28][C:29]1[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>O.C(O)C>[C:19]([NH:27][NH:28][C:29]1[CH:30]=[CH:31][C:32]([NH:35][C:12]([NH:35][C:32]2[CH:31]=[CH:30][C:29]([NH:28][NH:27][C:1](=[O:4])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:34][CH:33]=2)=[S:18])=[CH:33][CH:34]=1)(=[O:26])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 806183,5-Dithia-4-thioxo-1,7-heptanedioic acidHCID 20508846N'-(4-Aminophenyl)benzohydrazide

생성물 1

HCID 214278171,3-Bis[4-(2-benzoylhydrazino)phenyl]thiourea

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Sodium carbonate (4.65 g, 0.044 mole) was dissolved in a solvent mixture of water (95 ml) and ethanol (30 ml). Bis(carboxymethyl)trithiocarbonate (2.5 g, 0.011 mole) was added portionwise. Vigorous stirring of the reaction mixture was maintained until all solid was dissolved. It was then heated to 80°-85° C and 1-benzoyl-2-(4-aminophenyl)hydrazine (5.0 g, 0.022 mole) was added in one portion. Stirring and heating were maintained for one and one-half hour and the reaction mixture was then chilled. The solid was removed by filtration, washed and dried. Yield 2.05 g (37%), m.p. 185°-187° C.

후처리

  1. temperaturewas maintained until all solid
  2. dissolutionwas dissolved
  3. temperatureIt was then heated to 80°-85° C
  4. stirringStirring
  5. temperatureheating
  6. temperaturewere maintained for one and one-half hour
  7. temperaturethe reaction mixture was then chilled
  8. customThe solid was removed by filtration
  9. washwashed
  10. customdried

출처 및 근거

ORD 기록
ord-32d4633a0c2142058be403c8811ea4c0
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04030925

연결된 노트

불러오는 중…