4-Chlorobenzoyl chloride → 4-Chlorobenzoic N2-(4-nitrophenyl)hydrazide

HRID 437300

반응식

HRID 437300 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][NH2:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][CH:14]=1>C(#N)C>[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17]([NH:11][NH:10][C:7]2[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=2)=[O:18])=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 85014-Chlorobenzoyl chlorideHCID 3310889(4-Nitrophenyl)hydrazine

생성물 1

HCID 31065344-Chlorobenzoic N2-(4-nitrophenyl)hydrazide

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

반응 조건

온도
0 °C

실험 절차

4-Nitrophenylhydrazine (32.0 g, 0.21 mole) was slurried in acetonitrile (500 ml) and the mixture was cooled to 0° C. A solution of 4-chlorobenzoyl chloride (17.5 g, 0.10 mole) in acetonitrile (25 ml) was added dropwise to the cooled slurry. The reaction mixture was allowed to stand overnight. The mixture was filtered and the solid was washed with acetonitrile, then thoroughly with water. The product was recrystallized from acetonitrile and decolorized with charcoal to give a pale yellow solid. Yield 24.8 g (85%) m.p. 245.5°-248.5° C.

후처리

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with acetonitrile
  3. customThe product was recrystallized from acetonitrile
  4. customto give a pale yellow solid

출처 및 근거

ORD 기록
ord-dcc1940639ff4d9292a6efc96f2e2c56
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04030925

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