Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Thiazolecarboxylic acid → HCID 86648680, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Thiazolecarboxylic acid | HCID 304271 | — |
| 반응물 | cis(+/-)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride | HCID 86648665 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 86648680 | HCID 86648680 | 42.2% |
반응 단계
cis(±)-4-Chloro-N-(3-ethoxypiperidin-4-yl)-5-ethyl-1H-imidazole-2-carboxamide hydrochloride obtained in Example (131a) (100 mg, 0.297 mmol) and 4-thiazolecarboxylic acid (39 mg, 0.30 mmol) were suspended in DMF (3 mL). The suspension was subjected to the same operation as in Example (138a) to obtain 51.6 mg of the title compound as a colorless solid (42%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536197B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-06d8a7175859426fac1988f1cf2a7ff1 |
| 출처 메모 | uspto-grants-2013_09 |