Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | tert-Butoxycarbonyl-D-leucine | HCID 637604 | — |
| 반응물 | BOC-D-alanine | HCID 637606 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine | HCID 53724831 | — |
반응 단계
Nα-t-Butoxycarbonyl-D-leucine resin (53 g., 42.9 mmol) is deprotected as in part (b), and Nα-t-butoxycarbonyl-D-alanine (8.5 g., 45 mmol) is added followed by the addition of dicyclohexylcarbodiimide, 9.3 g., 45 mmol in chloroform, after 15 to 30 minutes, followed by agitation for 18 hours. The product is separated by filtration and washed three times with dichloromethane, 250 ml., and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04031071 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-a9f21c9effb14dcaa24c62b65729a608 |
| 출처 메모 | uspto-grants-1977_06 |