Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine

HRID 437331

반응식

HRID 437331 반응식
C(OC([NH:8][C@@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=O)(C)(C)C.[C:17]([O:21][C:22]([NH:24][C@@H:25]([C:27]([OH:29])=O)[CH3:26])=[O:23])([CH3:20])([CH3:19])[CH3:18].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[C:17]([O:21][C:22]([NH:24][C@@H:25]([C:27]([NH:8][C@@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:29])[CH3:26])=[O:23])([CH3:18])([CH3:19])[CH3:20]

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 637604tert-Butoxycarbonyl-D-leucineHCID 637606BOC-D-alanine

생성물 1

HCID 53724831Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Nα-t-Butoxycarbonyl-D-leucine resin (53 g., 42.9 mmol) is deprotected as in part (b), and Nα-t-butoxycarbonyl-D-alanine (8.5 g., 45 mmol) is added followed by the addition of dicyclohexylcarbodiimide, 9.3 g., 45 mmol in chloroform, after 15 to 30 minutes, followed by agitation for 18 hours. The product is separated by filtration and washed three times with dichloromethane, 250 ml., and dried.

후처리

  1. additionis added
  2. customThe product is separated by filtration
  3. washwashed three times with dichloromethane, 250 ml
  4. custom, and dried

출처 및 근거

ORD 기록
ord-a9f21c9effb14dcaa24c62b65729a608
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031071

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