4-(Chloromethyl)phenylacetic acid → Phenylacetic Acid

HRID 437353노트

반응식

HRID 437353 반응식
ClC[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.O1CCN(NC(=S)[S-])CC1>CO>[C:6]1([CH2:9][C:10]([OH:12])=[O:11])[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=1

참가 물질

4

반응물 2

HCID 103134194-(Chloromethyl)phenylacetic acidHCID 21792278Morpholinodithiocarbamate

생성물 1

HCID 999Phenylacetic Acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 1.85 g (0.01 mole) of 4-chloromethylphenyl acetic acid and 6.25 g (0.025 mole) of freshly prepared morpholinodithiocarbamate salt in 250 ml of methanol was stirred under nitrogen for 20 hours at room temperature. The solvent was evaporated, water was added and the solution was acidified to pH 1 using aqueous 10% hydrochloric acid then extracted with ethylacetate, dried over anhydrous magnesium sulfate and evaporated. The residue was recrystallized from ethylacetate to give p-morpholinodithiocarbamatemethyl)phenylacetic acid. M.P. 163° C.

후처리

  1. customThe solvent was evaporated
  2. additionwater was added
  3. extractionthen extracted with ethylacetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customevaporated
  6. customThe residue was recrystallized from ethylacetate

출처 및 근거

ORD 기록
ord-e96337b4aaed454dba47a3b07ac2578c
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031083

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