3-Bromo-1-propanol → HCID 13239624, 화합물

HRID 437386

반응식

HRID 437386 반응식
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[NH:3]1.Br[CH2:10][CH2:11][CH2:12][OH:13]>C1(C)C(C)=CC=CC=1>[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:10][CH2:11][CH2:12][OH:13]

참가 물질

4

반응물 2

HCID 123083-Bromo-1-propanolHCID 641768rel-(2R,6S)-2,6-Dimethylpiperidine

생성물 1

HCID 13239624HCID 13239624, 화합물

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A stirred solution of 460 g. of cis-2,6-dimethylpiperidine in 300 ml. of xylene is treated with 278 g. of 3-bromopropanol over a period of 15 minutes. The mixture is stirred and heated at reflux for 2 hours, then allowed to cool while stirring for 16 hours. The mixture is filtered and the filtrate evaporated at reduced pressure. The residue is distilled at reduced pressure to give cis-2,6-dimethyl-1-piperidinepropanol; b.p. 147°-149° C./25 mm.

후처리

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. temperatureto cool
  4. stirringwhile stirring for 16 hours
  5. filtrationThe mixture is filtered
  6. customthe filtrate evaporated at reduced pressure
  7. distillationThe residue is distilled at reduced pressure

출처 및 근거

ORD 기록
ord-c4a51d1f1ffb49698711afb4b5e819b1
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031101

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