Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bicarbonate Ion → Fluoromidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bicarbonate Ion | HCID 769 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | 1-(METHYLSULFONYLOXY)-6-CHLORO-2-(TRIFLUOROMETHYL)-1H-IMIDAZO(4,5-b)PYRIDINE | HCID 20359924 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Fluoromidine | HCID 911208 | 73% |
반응 단계
1-(Methylsulfonyloxy)-6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine (20 milligrams) in 0.5 milliliter of acetone was treated with 0.1 gram of sodium iodide in 0.5 milliliter of acetone. The reaction mixture was shaken with ether and bicarbonate solution. The ether portion was dried over magnesium sulfate and evaporated, yielding 10 milligrams (about 73 percent) of 6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04031107 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-fde4c1ece5ef45c68a2011d043d95a1d |
| 출처 메모 | uspto-grants-1977_06 |