Thionyl bromide → Fluoromidine

HRID 437403

반응식

O[N:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[N:4]=[C:3]1[C:12]([F:15])([F:14])[F:13].S(Br)(Br)=O>>[Cl:11][C:8]1[CH:9]=[C:10]2[NH:2][C:3]([C:12]([F:13])([F:14])[F:15])=[N:4][C:5]2=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 68176Thionyl bromide

HCID 30824181-Hydroxyfluromidine

생성물 1

HCID 911208Fluoromidine

실험 절차

Also, 6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine was prepared by reduction of 1-hydroxy-6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine with thionyl bromide.

출처 및 근거

ORD 기록: ord-fccab41be71d4898989f4f397afb86ff
출처 데이터셋: uspto-grants-1977_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04031107

연결된 노트

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