Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | methyl L-prolinate hydrochloride | HCID 2733200 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester | HCID 67548889 | 100% |
반응 단계
L-proline methyl ester hydrochloride (0.300 g, 1.81 mmol) was dissolved in dichloromethane (5 ml). Triethylamine (0.202 g, 1.99 mmol) and 1,1′-carbonylbis-1H-imidazole (0.352 g, 2.17 mmol) were added, and the mixture was stirred at room temperature for five days. Water was added to the reaction solution, followed by extraction with dichloromethane. Then, the organic layer was washed with brine and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, 0.404g of the title compound was obtained as a colorless oily substance (100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536197B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-86d9760c76fb49ea90d9def8ad4650fb |
| 출처 메모 | uspto-grants-2013_09 |