Water → 1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester

HRID 43745

반응식

HRID 43745 반응식
Cl.[CH3:2][O:3][C:4](=[O:10])[C@@H:5]1[CH2:9][CH2:8][CH2:7][NH:6]1.C(N(CC)CC)C.[C:18](N1C=CN=C1)([N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)=[O:19].O>ClCCl>[CH3:2][O:3][C:4](=[O:10])[C@@H:5]1[CH2:9][CH2:8][CH2:7][N:6]1[C:18]([N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)=[O:19]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 2733200methyl L-prolinate hydrochloride

생성물 1

HCID 675488891-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

L-proline methyl ester hydrochloride (0.300 g, 1.81 mmol) was dissolved in dichloromethane (5 ml). Triethylamine (0.202 g, 1.99 mmol) and 1,1′-carbonylbis-1H-imidazole (0.352 g, 2.17 mmol) were added, and the mixture was stirred at room temperature for five days. Water was added to the reaction solution, followed by extraction with dichloromethane. Then, the organic layer was washed with brine and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, 0.404g of the title compound was obtained as a colorless oily substance (100%).

후처리

  1. extractionfollowed by extraction with dichloromethane
  2. washThen, the organic layer was washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentration under reduced pressure

출처 및 근거

ORD 기록
ord-86d9760c76fb49ea90d9def8ad4650fb
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

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