Butyl Isothiocyanate → 3-Butyl-1-[4-(2-formylhydrazino)phenyl]thiourea

HRID 437508

반응식

HRID 437508 반응식
[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)=[O:2].[CH2:12]([N:16]=[C:17]=[S:18])[CH2:13][CH2:14][CH3:15]>C(O)C>[CH2:12]([NH:16][C:17](=[S:18])[NH:11][C:8]1[CH:9]=[CH:10][C:5]([NH:4][NH:3][CH:1]=[O:2])=[CH:6][CH:7]=1)[CH2:13][CH2:14][CH3:15]

참가 물질

4

반응물 2

HCID 11613Butyl IsothiocyanateHCID 113189Hydrazinecarboxaldehyde, 2-(4-aminophenyl)-

생성물 1

HCID 214278143-Butyl-1-[4-(2-formylhydrazino)phenyl]thiourea

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-Formyl-2-(4-aminophenyl)hydrazine (7.5 g, 0.05 mole) and butyl isothiocyanate (5.7 g, 0.05 mole) were mixed in ethanol (120 ml) and the mixture was refluxed for 30 minutes. The resulting solution was chilled in ice and upon scratching the product crystallized out as a white solid. The mixture was filtered and the solid was washed with ether. The product was dried to give a pale tan crystalline powder. Yield 9.8 g (74%), m.p. 129°-131° C.

후처리

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureThe resulting solution was chilled in ice
  3. customcrystallized out as a white solid
  4. filtrationThe mixture was filtered
  5. washthe solid was washed with ether
  6. customThe product was dried
  7. customto give a pale tan crystalline powder

출처 및 근거

ORD 기록
ord-634785fa5bdd4c95b79e83f97e19bd12
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031127

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