Ethyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate → HCID 86648704, 화합물

HRID 43756

반응식

HRID 43756 반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH:21]=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30]

참가 물질

3

반응물 1

HCID 86648702Ethyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate

생성물 1

HCID 86648704HCID 86648704, 화합물수율 46.7%

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

The same operation as in Example (160c) was performed using methyl cis(±)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-2-carboxylate obtained in Example (162a) (436 mg) and a 10% palladium-carbon catalyst (500 mg), to obtain 137.5 mg of the title compound as a colorless oily substance. The resulting compound was used for the next reaction without purification.

출처 및 근거

ORD 기록
ord-b45a3f68b1834f8fbaca54f8e2cceaed
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

연결된 노트

불러오는 중…