Thionyl Chloride → 4-Fluoro-2-nitrobenzoyl chloride

HRID 437619

반응식

HRID 437619 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.S(Cl)([Cl:16])=O>C1C=CC=CC=1>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:16])=[O:7])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 27374164-Fluoro-2-nitrobenzoic acid

생성물 1

HCID 133524084-Fluoro-2-nitrobenzoyl chloride

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a stirred mixture of 76 parts of 4-fluoro-2-nitrobenzoic acid and 225 parts of benzene are added dropwise 71 parts of sulfinyl chloride. Upon completion, stirring is continued first for 5 hours at reflux and further overnight at room temperatue. The reaction mixture is evaporated. The residue is taken up twice in benzene and the latter is evaporated each time, yielding 85 parts of 4-fluoro-2-nitrobenzoyl chloride as a residue.

후처리

  1. temperatureat reflux and further overnight at room temperatue
  2. customThe reaction mixture is evaporated
  3. customthe latter is evaporated each time

출처 및 근거

ORD 기록
ord-f6d8aff7fb8f461c8cfc83818fd92f64
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031226

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