Benzene → HCID 21428866, 화합물

HRID 437624

반응식

HRID 437624 반응식
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]2[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[C:13]1([N:19]2[C:23]3([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:22](=[O:29])[NH:21][CH2:20]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1C=CC=CC=1>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:10][CH2:9][N:26]2[CH2:25][CH2:24][C:23]3([N:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH2:20][NH:21][C:22]3=[O:29])[CH2:28][CH2:27]2)=[O:7])=[CH:11][CH:12]=1

참가 물질

5

반응물 3

HCID 241BenzeneHCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 2450271-(4-Chlorobenzoyl)aziridine

생성물 1

HCID 21428866HCID 21428866, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1.82 parts of 1-(4-chlorobenzoyl)aziridine, 2.32 parts of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one, 10.8 parts of benzene an 1.6 parts of methanol is stirred and refluxed for 1.50 hours. The reaction mixture is cooled and upon scratching, the product solidifies. It is filtered off, washed with benzene and crystallized from 2-propanol, yielding 1.53 parts of 4-chloro-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]benzamide; mp. 200.6° C.

후처리

  1. temperaturerefluxed for 1.50 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationIt is filtered off
  4. washwashed with benzene
  5. customcrystallized from 2-propanol

출처 및 근거

ORD 기록
ord-8f8b1ee3f79b4e99b20ada9df39c2347
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031226

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