Ethanolamine → N-(2-Hydroxyethyl)picolinamide

HRID 437650

반응식

HRID 437650 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][CH2:12][CH2:13][OH:14]>>[OH:14][CH2:13][CH2:12][NH:11][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:9]

참가 물질

3

반응물 2

HCID 700EthanolamineHCID 755692-Carbomethoxypyridine

생성물 1

HCID 2045999N-(2-Hydroxyethyl)picolinamide

실험 절차

A mixture of 72 parts of methyl 2-pyridinecarboxylate and 32 parts of 2-aminoethanol is stirred and refluxed carefully for 2 hours. The reaction mixture is cooled and poured onto water. The product is extracted five times with trichloromethane. The combined extracts are dried, filtered and evaporated, yielding 49 parts of N-(2-hydroxyethyl)-2-pyridinecarboxamide as a residue.

후처리

  1. temperaturerefluxed carefully for 2 hours
  2. temperatureThe reaction mixture is cooled
  3. additionpoured onto water
  4. extractionThe product is extracted five times with trichloromethane
  5. customThe combined extracts are dried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-5704bb8efb124950a0793cacfb9bcc3f
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031226

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