Methyl cis(+/-)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate → Methyl cis(+/-)-4-(4-amino-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate

HRID 43767노트

반응식

HRID 43767 반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([CH3:24])[N:21]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[CH:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30]

참가 물질

3

반응물 1

HCID 86648714Methyl cis(+/-)-4-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate

생성물 1

HCID 86648716Methyl cis(+/-)-4-(4-amino-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate수율 100.5%

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

The same operation as in Example (160c) was performed using methyl cis(±)-4-(4-{[benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-2-carboxylate obtained in Example (168a) (190 mg) and a 10% palladium-carbon catalyst (200 mg), to obtain 129 mg of the title compound as a colorless oily substance. The resulting compound was used for the next reaction without purification.

출처 및 근거

ORD 기록
ord-8016605de55941dca4f74f0127d2d046
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

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