Water → 6-Bromo-1,2,3,9-tetrahydro-4H-carbazol-4-one

HRID 4377노트

반응식

HRID 4377 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]N=C2CCCC(=O)C2)=[CH:4][CH:3]=1.[OH2:17]>C(O)(=O)C.[Cl-].[Zn+2].[Cl-]>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[NH:8][C:3]1[CH2:4][CH2:5][CH2:6][C:7](=[O:17])[C:2]2=1

참가 물질

5

반응물 2

HCID 962WaterHCID 566239871,3-Cyclohexanedione mono(4-bromophenylhydrazone)

생성물 1

HCID 201524426-Bromo-1,2,3,9-tetrahydro-4H-carbazol-4-one

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 176Acetic Acid용매

실험 절차

The product of Stage (i) (1.5 g) was heated under reflux with dry zinc chloride (16 g) in glacial acetic acid (75 ml) for 24 h. The mixture was cooled, poured into water (200 ml), and the resulting solid filtered off and dried (0.95 g). Purification by flash chromatography (E) gave the title compound as a solid (125 mg). T.l.c. (F), Rf 0.65

후처리

  1. temperatureThe mixture was cooled
  2. filtrationthe resulting solid filtered off
  3. customdried (0.95 g)
  4. customPurification by flash chromatography (E)

출처 및 근거

ORD 기록
ord-477e144581644ea4bec3777f5ed06716
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725615

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