Chlorine → 4'-Chloro-2'-fluoroacetanilide

HRID 437701

반응식

HRID 437701 반응식
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[NH:4][C:5](=[O:7])[CH3:6].[Cl:12]Cl>C(O)(=O)C>[Cl:12][C:10]1[CH:9]=[CH:8][C:3]([NH:4][C:5](=[O:7])[CH3:6])=[C:2]([F:1])[CH:11]=1

참가 물질

4

반응물 2

HCID 24526ChlorineHCID 67860N-(2-Fluorophenyl)acetamide

생성물 1

HCID 8531744'-Chloro-2'-fluoroacetanilide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 140 parts of 2'-fluoroacetanilide in 500 parts glacial acetic acid was treated with 71 parts of chlorine during one hour at 25°-27° C. with ice-water cooling. While stirring for 4 hours at 25°- 27° C., 4'-chloro-2'-fluoroacetanilide precipitated. After collecting the product by filtration, the filtrate was poured over 2000 parts of ice. The resulting second portion of product precipitated was collected by filtration, combined with the first portion and recrystallized from 700 parts of methanol at -45° C. to yield 119 parts of 4'-chloro-2'-fluoroacetanilide as white crystals melting at 152°-155° C.

후처리

  1. custom4'-chloro-2'-fluoroacetanilide precipitated
  2. customAfter collecting the product
  3. filtrationby filtration
  4. additionthe filtrate was poured over 2000 parts of ice
  5. customThe resulting second portion of product precipitated
  6. filtrationwas collected by filtration
  7. customrecrystallized from 700 parts of methanol at -45° C.

출처 및 근거

ORD 기록
ord-fba8ed17b6f944e581964e4701ca8950
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04032326

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