Hydrogen Peroxide → 5-Amino-3-isopropylisothiazole-4-carbonitrile

HRID 437710노트

반응식

HRID 437710 반응식
OO.[NH2:3][C:4]([CH:11]([CH3:13])[CH3:12])=[C:5]([C:9]#[N:10])[C:6](=[S:8])[NH2:7]>C(O)C>[NH2:7][C:6]1[S:8][N:3]=[C:4]([CH:11]([CH3:13])[CH3:12])[C:5]=1[C:9]#[N:10]

참가 물질

4

반응물 2

HCID 784Hydrogen PeroxideHCID 73793209HCID 73793209, 화합물

생성물 1

HCID 152801535-Amino-3-isopropylisothiazole-4-carbonitrile수율 97%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

While maintaining the temperature below 50°, 86.1 g of 30% hydrogen peroxide was added dropwise to a solution of 128.3 g of 3-amino-2-cyano-4-methyl- 2-pentenethioamide in 600 ml of absolute ethanol. The mixture was stirred at room temperature for 19 hours, filtered and concentrated to about half volume. Water was added to cloud point and the solid allowed to separate. The solid was collected and dried to give 123.0 g of 5-amino-4-cyano-3-isopropylisothiazole, mp 133°-135°.

후처리

  1. filtrationfiltered
  2. concentrationconcentrated to about half volume
  3. additionWater was added to cloud point
  4. customto separate
  5. customThe solid was collected
  6. customdried

출처 및 근거

ORD 기록
ord-c228324b2154465c96f2234733245f4b
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04032322

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