Phenyl isocyanate → N-(2-(2-Oxo-1-imidazolidinyl)ethyl)-N'-phenylurea

HRID 437938

반응식

HRID 437938 반응식
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:8][CH2:7][NH:6][C:5]1=[O:9].[C:10]1([N:16]=[C:17]=[O:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C1C=CC=CC=1>[O:9]=[C:5]1[NH:6][CH2:7][CH2:8][N:4]1[CH2:3][CH2:2][NH:1][C:17]([NH:16][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:18]

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 80480N-(2-Aminoethyl)ethyleneurea

생성물 1

HCID 115176N-(2-(2-Oxo-1-imidazolidinyl)ethyl)-N'-phenylurea

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a mixture of 6.5 g of commercially available 1-(2-aminoethyl)-2-imidazolidone and 50 ml benzene was added 5.5 ml of phenyl isocyanate. The strongly exothermic reaction was moderated by cooling to 25°. The mixture was stirred at 25° for 4 hr. It was cooled in ice and the mixture was filtered. The solid product was crystallized from 250 ml of acetone to give 6.8 g of white 1-[2-(2-oxo-1-imidazolidinyl)-ethyl]-3-phenylurea, mp 162- 164°.

후처리

  1. customThe strongly exothermic reaction
  2. temperatureby cooling to 25°
  3. temperatureIt was cooled in ice
  4. filtrationthe mixture was filtered
  5. customThe solid product was crystallized from 250 ml of acetone

출처 및 근거

ORD 기록
ord-441860d9ce3044f092afb72e536f3b79
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04032638

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