Sodium Carbonate → Ethyl trans(+/-)-2-[3-(benzylamino)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidin-1-yl]-4-methyl-1,3-thiazole-5-carboxylate
반응식
[CH2:1]([NH:8][C@H:9]1[C@H:14]([NH:15][C:16]([C:18]2[NH:19][C:20]([CH2:24][CH3:25])=[C:21]([Cl:23])[N:22]=2)=[O:17])[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.O1CCOCC1.Br[C:41]1[S:42][C:43]([C:47]([O:49][CH2:50][CH3:51])=[O:48])=[C:44]([CH3:46])[N:45]=1.C(=O)([O-])[O-].[Na+].[Na+]>>[CH2:1]([NH:8][C@H:9]1[C@H:14]([NH:15][C:16]([C:18]2[NH:19][C:20]([CH2:24][CH3:25])=[C:21]([Cl:23])[N:22]=2)=[O:17])[CH2:13][CH2:12][N:11]([C:41]2[S:42][C:43]([C:47]([O:49][CH2:50][CH3:51])=[O:48])=[C:44]([CH3:46])[N:45]=2)[CH2:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
5
반응물 4
생성물 1
실험 절차
The same operation as in Example (196c) was performed using tert-butyl trans(±)-3-(benzylamino)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}piperidine-1-carboxylate obtained in Example (203a) (50.0 mg, 0.108 mmol), 4 N hydrochloric acid/1,4-dioxane (1 mL), ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate (32 mg, 0.130 mmol) and sodium carbonate (115 mg, 1.08 mmol), to obtain 12 mg of the title compound (21%) as a colorless solid.
출처 및 근거
- ORD 기록
- ord-01f7f54bb1e04780bc2dcebfcb00d977
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08536197B2
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