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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Staurosporine → Staurosporine

HRID 439106
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HRID 439106 반응식
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4.Cc1cc(C=O)no1>CC(=O)O.CC(=O)O[BH-](OC(C)=O)OC(C)=O.CC(C)[O-].CC(C)[O-].CC(C)[O-].CC(C)[O-].CN1CCCC1=O.[Na+].[Ti+4]>CO[C@@H]1[C@H](N(C)Cc2cc(C)on2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
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참가 물질

9

반응물 2

HCID 44259StaurosporineHCID 27952225-Methyl-1,2-oxazole-3-carbaldehyde

생성물 3

HCID 44259StaurosporineHCID 27952225-Methyl-1,2-oxazole-3-carbaldehydeHCID 178496683HCID 178496683, 화합물

시약·촉매·용매 4

HCID 176Acetic Acid시약HCID 11026Titanium isopropoxide시약HCID 5049666Sodium triacetoxyborohydride시약HCID 13387N-methyl-2-pyrrolidone용매7회

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온도
22 °C

후처리

  1. additionThe next morning, the Mosquito(R) was used to dilute the 100 mM reactions to 50 mM via addition of 1 uL DMSO to each reaction well, followed by dispense mixing.
  2. additionThe reactions were quenched with 1 uL saturated aqueous NaHCO3.
  3. additionThe reactions were quenched with 1 uL water.
  4. additionThe reactions were diluted to approximately 10 mM.
  5. aliquotMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.
  6. additionMosquito(R) was used to transfer 1 uL of each quenched reaction from the 1,536-well reaction plate to 384-well analytical plates containing 60 uL DMSO for analysis by UPLC.

출처 및 근거

ORD 기록
ord-688f64c751fb49d78006ac84acc50eae
출처 데이터셋
Cernak miniaturized reductive amination
DOI
10.1038/s44160-023-00351-1
원본 링크
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