2-Chloropyridine → Tert-butyl 2-pyridin-2-ylpyrrole-1-carboxylate

HRID 439186노트

반응식

HRID 439186 반응식
CC(C)(C)OC(=O)n1cccc1B(O)O.Clc1ccccn1>C1CCC2=NCCCN2CC1.C1CCOC1.CC(C)(C)P(C(C)(C)C)C(C)(C)C.CS(=O)(=O)[O][Pd][c]1ccccc1-c1ccccc1N.O>CC(C)(C)OC(=O)n1cccc1-c1ccccn1

참가 물질

10

반응물 2

HCID 79772-ChloropyridineHCID 27343211-(tert-Butoxycarbonyl)-2-pyrroleboronic Acid

생성물 1

HCID 86058205Tert-butyl 2-pyridin-2-ylpyrrole-1-carboxylate수율 23.7%

시약·촉매·용매 7

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene시약HCID 178454885HCID 178454885, 화합물촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매5회HCID 180Acetone후처리HCID 931Naphthalene내부 표준HCID 962Water후처리

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온도
110 °C

후처리

  1. additionAs soon as the slug leaves the reactor and is detected at PS2,a quench solution volume equal to the reaction slug volume(prepared slug volume + base injection volume) is injected into the reaction slug

출처 및 근거

ORD 기록
ord-5b5cd7e02bb44cdfa2f90ad55d7f2328
출처 데이터셋
Reizman Suzuki Cross-Coupling
원본 링크
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