2-Chloropyridine → Tert-butyl 2-pyridin-2-ylpyrrole-1-carboxylate

HRID 439188노트

반응식

HRID 439188 반응식
CC(C)(C)OC(=O)n1cccc1B(O)O.Clc1ccccn1>C1CCC2=NCCCN2CC1.C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Nc1ccccc1-c1cccc[c]1[Pd][Cl].O>CC(C)(C)OC(=O)n1cccc1-c1ccccn1

참가 물질

10

반응물 2

HCID 79772-ChloropyridineHCID 27343211-(tert-Butoxycarbonyl)-2-pyrroleboronic Acid

생성물 1

HCID 86058205Tert-butyl 2-pyridin-2-ylpyrrole-1-carboxylate수율 50.3%

시약·촉매·용매 7

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene시약HCID 178439015HCID 178439015, 화합물촉매HCID 962Water용매HCID 8028Tetrahydrofuran용매5회HCID 180Acetone후처리HCID 931Naphthalene내부 표준HCID 962Water후처리

반응 조건

온도
110 °C

후처리

  1. additionAs soon as the slug leaves the reactor and is detected at PS2,a quench solution volume equal to the reaction slug volume(prepared slug volume + base injection volume) is injected into the reaction slug

출처 및 근거

ORD 기록
ord-58d667b0de334846a724c07e1f2bdf95
출처 데이터셋
Reizman Suzuki Cross-Coupling
원본 링크
출처 보기

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