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Phosphorus pentachloride → HCID 54344002, 화합물

HRID 439295
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HRID 439295 반응식
[CH2:1]([NH:8][C:9]1[S:10][C:11]([C:15]([OH:17])=O)=[C:12]([CH3:14])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(NC1SC(C(Cl)=O)=C(C)N=1)C1C=CC=CC=1.P(Cl)(Cl)(Cl)(Cl)Cl.Cl.[NH2:42][CH:43]([C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)[C:44]#[N:45]>C(N(CC)CC)C>[C:44]([CH:43]([NH:42][C:15]([C:11]1[S:10][C:9]([NH:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[N:13][C:12]=1[CH3:14])=[O:17])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)#[N:45]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 24819Phosphorus pentachlorideHCID 1132751HCID 1132751, 화합물HCID 27237172-Phenylglycinonitrile hydrochlorideHCID 53827267HCID 53827267, 화합물

생성물 1

HCID 54344002HCID 54344002, 화합물수율 39%

시약·촉매·용매 1

HCID 8471Triethylamine
용매

실험 절차

1.2g of 2-benzylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-benzylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.1g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 0.89g of amino-phenylacetonitrile hydrochloride and 2.3ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.68g (Yield 39%) of the title compound.

후처리

  1. additionthe reaction mixture was treated

출처 및 근거

ORD 기록
ord-e33c1b1de13e42bbb4fc74fc7960682d
출처 데이터셋
uspto-grants-1996_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05514643

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