Allylamine → 2-Allylamino-4-ethyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide
반응식
[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15](Br)=[N:14][C:13]=1[CH2:18][CH3:19])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)#[N:2].C(N(CC)CC)C.[CH2:27]([NH2:30])[CH:28]=[CH2:29]>O1CCCC1>[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:30][CH2:27][CH:28]=[CH2:29])=[N:14][C:13]=1[CH2:18][CH3:19])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)#[N:2]참가 물질
5
실험 절차
1.0g of 2-bromo-4-ethyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide, 0.40ml of triethylamine and 0.66ml of allylamine were added to 10ml of tetrahydrofuran. The reaction mixture was stirred under reflux for 12 hours and then treated according to the same procedure as EXAMPLE 10 to obtain 0.57g (Yield 61%) of the title compound.