Hydrogen Sulfide → HCID 54512368, 화합물

HRID 439300노트

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HRID 439300 반응식
[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:17][CH2:18][CH3:19])=[N:14][C:13]=1[CH3:20])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[SH2:21]>N1C=CC=CC=1>[C:1]([CH:3]([NH:9][C:10]([C:12]1[S:16][C:15]([NH:17][CH2:18][CH3:19])=[N:14][C:13]=1[CH3:20])=[O:11])[C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[S:21])[NH2:2]

참가 물질

4

반응물 2

HCID 402Hydrogen SulfideHCID 22465462HCID 22465462, 화합물

생성물 1

HCID 54512368HCID 54512368, 화합물수율 91%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
60 °C

실험 절차

0.85g of 2-ethylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide (5) was dissolved in 2ml of pyridine and the reaction solution was stirred for 6 hours at 60° C. while introducing hydrogen sulfide gas. After removing the pyridine, the residue was recrystallized from ethylacetate to obtain 0.86g (Yield 91%) of the title compound.

후처리

  1. customAfter removing the pyridine
  2. customthe residue was recrystallized from ethylacetate

출처 및 근거

ORD 기록
ord-cf354ad9ab3346b7b0f91ff67c255bb9
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05514643

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