Benzenesulfonyl chloride, 2,5-dimethyl- → 2,5-Dimethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide

반응식

[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[S:17](Cl)(=[O:19])=[O:18]>>[CH3:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:11]=1[S:17]([NH:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8])(=[O:18])=[O:19]

참가 물질

반응물 2

HCID 87910Benzenesulfonyl chloride, 2,5-dimethyl-

HCID 104875194-Bromo-3-methylisoxazol-5-amine

생성물 1

HCID 186173772,5-Dimethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide수율 81%

실험 절차

2, 5-Dimethyl-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 2,5-dimethylbenzenesulfonyl chloride according to the procedures described in Example 1b. The crude product was purified by recrystallization from ethyl acetate/hexanes to give off-white crystals, m.p. 102°-104° C., yield 81%.

후처리

customThe crude product was purified by recrystallization from ethyl acetate/hexanes
customto give off-white crystals, m.p. 102°-104° C., yield 81%

출처 및 근거

ORD 기록: ord-3673a74728754d9badfa9442000f987a
출처 데이터셋: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05514691

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