5-Bromovanillin → N-(3-chlorophenyl)-2-cyano-3-(3-bromo-4-hydroxy-5-methoxyphenyl) propenamide

HRID 439557

반응식

HRID 439557 반응식
[Br:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=O.[Cl:13][C:14]1[CH:15]=[C:16]([NH:20][C:21](=[O:25])[CH2:22][C:23]#[N:24])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[CH:15]=[C:16]([NH:20][C:21](=[O:25])[C:22]([C:23]#[N:24])=[CH:7][C:6]2[CH:5]=[C:4]([O:10][CH3:11])[C:3]([OH:12])=[C:2]([Br:1])[CH:9]=2)[CH:17]=[CH:18][CH:19]=1

참가 물질

3

반응물 2

HCID 180995-BromovanillinHCID 679494N-(3-chlorophenyl)-2-cyanoacetamide

생성물 1

HCID 53730904N-(3-chlorophenyl)-2-cyano-3-(3-bromo-4-hydroxy-5-methoxyphenyl) propenamide수율 65%

실험 절차

The reaction was performed in the same manner as in Example 1 with 5-bromovanillin (1.38 g, 5.97 mmol) and N-(3-chlorophenyl) cyanoacetamide (1.16 g, 5.97 mmol) to give the objective N-(3-chlorophenyl)-2-cyano-3-(3-bromo-4-hydroxy-5-methoxyphenyl) propenamide (1.58 g, 65% in yield).

출처 및 근거

ORD 기록
ord-4408703937e1495ea883d675cacea422
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05514711

연결된 노트

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