3-Fluoro-4-hydroxy-5-methoxybenzaldehyde → HCID 54180841, 화합물

HRID 439559

반응식

HRID 439559 반응식
[F:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=O.[Cl:13][C:14]1[CH:15]=[C:16]([NH:20][C:21](=[O:25])[CH2:22][C:23]#[N:24])[CH:17]=[CH:18][CH:19]=1>>[Cl:13][C:14]1[CH:15]=[C:16]([NH:20][C:21](=[O:25])[C:22]([C:23]#[N:24])=[CH:7][C:6]2[CH:5]=[C:4]([O:10][CH3:11])[C:3]([OH:12])=[C:2]([F:1])[CH:9]=2)[CH:17]=[CH:18][CH:19]=1

참가 물질

3

반응물 2

HCID 5984523-Fluoro-4-hydroxy-5-methoxybenzaldehydeHCID 679494N-(3-chlorophenyl)-2-cyanoacetamide

생성물 1

HCID 54180841HCID 54180841, 화합물수율 57%

실험 절차

The reaction was effected in the same manner as in Example 1 with 5-fluorovanillin (410 mg, 2.41 mmol) and N-(3-chlorophenyl) cyanoacetamide (469 mg, 2.41 mmol) to give the objective N-(3-chlorophenyl)-2-cyano-3-(3-fluoro-4-hydroxy-5-methoxyphenyl) propenamide (476 mg, 57% in yield) as yellow powders.

출처 및 근거

ORD 기록
ord-7fe3ff9d1db443bc88731c55ea01d699
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05514711

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