Dicyclohexylcarbodiimide → Pentafluorophenyl 4'-Octyloxy-biphenyl-4-carboxylate

HRID 439703

반응식

HRID 439703 반응식
[F:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([F:10])=[C:4]([F:11])[C:3]=1[F:12].[CH2:13]([O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34](O)=[O:35])=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].C1(N=C=NC2CCCCC2)CCCCC1>C(OCC)(=O)C>[CH2:13]([O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][C:31]([C:34]([O:8][C:7]3[C:2]([F:1])=[C:3]([F:12])[C:4]([F:11])=[C:5]([F:10])[C:6]=3[F:9])=[O:35])=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

5

반응물 3

HCID 10868DicyclohexylcarbodiimideHCID 13041PentafluorophenolHCID 28025564'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid

생성물 1

HCID 15548597Pentafluorophenyl 4'-Octyloxy-biphenyl-4-carboxylate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

반응 조건

온도
25 °C

실험 절차

Pentafluorophenol (11.5 mmol) is added at 0° to a mixture of 10.5 mmol 4'-n-octyloxy[1,1'-biphenyl]-4-ylcarboxylic acid and 10.5 mmol of dicyclohexylcarbodiimide in ethyl acetate. The mixture is stirred at 25° C. for a period of 18 hours whereupon a precipitate is formed. The reaction mixture is filtered, the filtrate washed with water and brine and dried, the solvent removed in vacuo to obtain pentafluorophenyl 4'-n-octyloxy[1,1'-biphenyl]-4-ylcarboxylate, C27H25F5O3, M.W. 492.5.

후처리

  1. customis formed
  2. filtrationThe reaction mixture is filtered
  3. washthe filtrate washed with water and brine
  4. customdried
  5. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-22c59a8dc8a74053acd9ec4f68dac0bc
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05516756

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