Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
o-Chloranil → ethyl 4-cyano-1,3-dimethyl-1H-indazole-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | o-Chloranil | HCID 73252 | — |
| 반응물 | ethyl 4-cyano-6,7-dihydro-1,3-dimethyl-1H-indazole-5-carboxylate | HCID 22402928 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | ethyl 4-cyano-1,3-dimethyl-1H-indazole-5-carboxylate | HCID 22402968 | 47.3% |
반응 단계
A mixture of ethyl 4-cyano-6,7-dihydro-1,3-dimethyl-1H-indazole-5-carboxylate (13.5 g, 55.0 mmol), o-chloranil (16.3 g, 66.0 mmol) and dry benzene is stirred for 1.5 hours at reflux temperature, cooled and filtered. The filtrate is concentrated in vacuo, filtered through two pads of neutral alumina and evaporated to dryness to afford a yellow solid. Recrystallization from ethyl acetate affords the title product (6.33 g, 47.2%), mp 170°-175.5° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05516751 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-7e6ef78a7e6149acbb5ce549f8594c87 |
| 출처 메모 | uspto-grants-1996_05 |