Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-(5-Methyl-2-phenyl-4-oxazolyl)ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Methyl (5-methyl-2-phenyl-1,3-oxazol-4-yl)acetate | HCID 2775318 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-(5-Methyl-2-phenyl-4-oxazolyl)ethanol | HCID 725585 | 96.5% |
반응 단계
A solution of methyl 5-methyl-2-phenyl-4-oxazoleacetate (54 g) in dry ethyl ether (150 ml) was added dropwise to a stirred, ice-cooled suspension of lithium aluminum hydride (8.8 g) in dry ethyl ether (700 ml) during 1.5 hours. Ethyl acetate (20 ml) was added dropwise thereto with ice-cooling and then water (50 ml) was added cautiously thereto. The resulting white precipitate was filtered off and the filtrate was concentrated to give 2-(5-methyl-2-phenyl-4-oxazolyl) ethanol as crystals (45.8 g, 96.2%). Recrystallization from ethyl acetate-hexane gave colorless rods, m.p. 73°-74° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04725610 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-55ea6960f61b4354bc71a258ea910ffe |
| 출처 메모 | uspto-grants-1988_02 |