Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(6-(Bis(carboxymethyl)amino)-5-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)-2-benzofuranyl)-5-oxazolecarboxylic acid → Fura F
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(6-(Bis(carboxymethyl)amino)-5-(2-(2-(bis(carboxymethyl)amino)-5-methylphenoxy)ethoxy)-2-benzofuranyl)-5-oxazolecarboxylic acid | HCID 57054 | — |
| 반응물 | Proton sponge | HCID 88675 | — |
| 반응물 | Bapta | HCID 104751 | — |
| 반응물 | 2,3-Difluoro-6-nitrophenol | HCID 2733745 | — |
| 반응물 | N,N'-[1,2-Ethanediylbis[oxy(4-fluoro-2,1-phenylene)]]bis[N-(carboxymethyl)glycine] | HCID 11027644 | — |
| 생성물 | Fura F | HCID 3025888 | — |
반응 단계
As discussed above, the synthesis of 5,5', 6,6'-tetrafluoro-BAPTA (Formula II) was carried out as originally described for both BAPTA and 5,5'-difluoro BAPTA starting from commercially available 2-nitro-5,6-difluorophenol. Fura-F was synthesized via the pathway originally described for the preparation of Fura-2. Unless otherwise noted commercially available reagents and dry solvents were used as received. Reactions were carried out under an atmosphere of argon and reaction temperatures refer to the bath. Flash column chromatography was performed with Merck Silica Gel 60 (40-63 μm). Proton sponge is 1,8-bis(dimethylamino)naphthalene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05516911 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-76d2846edae443ab9eed0f43a815ffed |
| 출처 메모 | uspto-grants-1996_05 |