Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Dimethylphenol → 2,6-Dimethylphenyl pentafluorobenzyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Dimethylphenol | HCID 11335 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | Pentafluorobenzyl bromide | HCID 74484 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2,6-Dimethylphenyl pentafluorobenzyl ether | HCID 11055754 | 96% |
반응 단계
A mixture of 2,6-dimethylphenol (5 mmol), pentafluorobenzyl bromide (1.3 g, 5 mmol), potassium carbonate (5 g), acetone (30 ml), and 18-crown-6 ether (0.1 g) were stirred under reflux for 5 hours. Work-up procedure was the same as above. Yield: 96%; m.p.: 81°-82° C.; 1H NMR, δ: 2.37 (s, 6H, CH3), 4.91 (s, 2H, CH2O), 6.96-7.16 (m, 3H, H-Ar) ppm; 13C NMR, δ: 15.7 (CH3), 59.9 (CH2O), 110.7 (C1', 2JC-F =18 Hz), 124.6 (C4), 129.0 (C3 & C5), 131.1 (C2 & C6), 137.6 (C2' & C6', JC-F =253 Hz), 141.7 (C4', JC-F =255 Hz), 145.9 (C3' & C5', JC-F =250 Hz ), 154.6 (C1) ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05516931 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-ba7575b8e544453dbc53edf8ee64ce8c |
| 출처 메모 | uspto-grants-1996_05 |