Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 1-(6-Methoxypyridin-2-yl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | 2-Chloro-6-methoxypyridine | HCID 87009 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Ammonia | HCID 222 | 28% |
| 생성물 | 1-(6-Methoxypyridin-2-yl)piperazine | HCID 12200470 | 62.1% |
반응 단계
In a sealed tube, 8.6 g of piperazine and 2.9 g (0.02 mole) of 2-chloro-6-methoxypyridine were reacted at 150° C. for 4 hours. After the reaction, the reaction mixture was applied to silica gel column chromatography (the eluent used was a mixture of chloroform: methanol : 28% aqueous ammonia = 40 : 9 : 1) to obtain 2.4 g of 1-(6-methoxy-2-pyridyl)piperazine as pale yellow liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05519016 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-ebced245ede149b797c0a7a977535614 |
| 출처 메모 | uspto-grants-1996_05 |