Phosgene → 9(+)-Fluorenylethyl chloroformate

HRID 440341노트

반응식

HRID 440341 반응식
[CH:1]1[C:13]2[CH:12]([CH2:14][CH2:15][OH:16])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:17](Cl)([Cl:19])=[O:18]>C1(C)C=CC=CC=1.O1CCCC1>[Cl:19][C:17]([O:16][CH2:15][CH2:14][CH:12]1[C:13]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=2[C:6]2[C:11]1=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:18]

참가 물질

5

반응물 2

HCID 6371PhosgeneHCID 10921761Fluorene-9-ethanol

생성물 1

HCID 149683719(+)-Fluorenylethyl chloroformate

시약·촉매·용매 2

HCID 1140Toluene용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-(9-fluorenyl)ethanol 1.26 g, 6 mmol) in 10 ml of toluene and 4 ml of tetrahydrofuran (THF), was added dropwise with stirring phosgene (12.4 ml, 1.93M solution in toluene). The solution was stirred for 0.5 hours, then put under vacuum to remove the phosgene. Concentration yielded 2-(9-fluorenyl)ethyl chloroformate (6 mmol, 1.64 g).

후처리

  1. customto remove the phosgene
  2. concentrationConcentration

출처 및 근거

ORD 기록
ord-36f818b704fd436e8a9947a25bcadd01
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05519043

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