Methanol → Methyl 2-(4-fluorophenyl)acetate

HRID 440384

반응식

HRID 440384 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12]O>S(=O)(=O)(O)O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 98372-(4-Fluorophenyl)acetic acid

생성물 1

HCID 2733233Methyl 2-(4-fluorophenyl)acetate

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

반응 조건

온도
50 °C

실험 절차

Combine 4-fluorophenylacetic acid (10.6 g, 68.8 mmol) and anhydrous methanol (100 mL). Add concentrated sulfuric acid (3 drops). Heat at 50° C. After 12 hours, cool to ambient temperature and evaporate most of the solvent in vacuo. Dilute the evaporated reaction mixture with ether, extract with aqueous saturated sodium bicarbonate solution and brine. Dry over MgSO4 filter and allow to stand until a solid forms. Collect the solid by filtration to give methyl 4-fluorophenylacetate which may be used without further purification.

후처리

  1. temperaturecool to ambient temperature
  2. customevaporate most of the solvent in vacuo
  3. additionDilute
  4. customthe evaporated reaction mixture with ether
  5. extractionextract with aqueous saturated sodium bicarbonate solution and brine
  6. dry with materialDry over MgSO4
  7. filtrationfilter
  8. customCollect the solid
  9. filtrationby filtration

출처 및 근거

ORD 기록
ord-e8e4633672dc4bd5998555ecc3cc0e41
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05519048

연결된 노트

불러오는 중…