Methanol → Methyl 2-(4-fluorophenyl)acetate
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12]O>S(=O)(=O)(O)O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=1참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
Combine 4-fluorophenylacetic acid (10.6 g, 68.8 mmol) and anhydrous methanol (100 mL). Add concentrated sulfuric acid (3 drops). Heat at 50° C. After 12 hours, cool to ambient temperature and evaporate most of the solvent in vacuo. Dilute the evaporated reaction mixture with ether, extract with aqueous saturated sodium bicarbonate solution and brine. Dry over MgSO4 filter and allow to stand until a solid forms. Collect the solid by filtration to give methyl 4-fluorophenylacetate which may be used without further purification.
후처리
- temperaturecool to ambient temperature
- customevaporate most of the solvent in vacuo
- additionDilute
- customthe evaporated reaction mixture with ether
- extractionextract with aqueous saturated sodium bicarbonate solution and brine
- dry with materialDry over MgSO4
- filtrationfilter
- customCollect the solid
- filtrationby filtration
출처 및 근거
- ORD 기록
- ord-e8e4633672dc4bd5998555ecc3cc0e41
- 출처 데이터셋
- uspto-grants-1996_05
- 특허 번호
- US05519048
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