Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → HCID 53986391, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Methyl formate | HCID 7865 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Methyl 2-(4-fluorophenyl)acetate | HCID 2733233 | — |
| 촉매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 53986391 | HCID 53986391 | — |
반응 단계
Suspend sodium hydride (3.4 g, 142 mmol) in anhydrous tetrahydrofuran (100 mL). Cool in an ice/water bath. Add methyl formate (8.8 mL, 142 mmol), methanol (1 drop), and methyl 4-fluorophenylacetate. Warm slowly to ambient temperature. After 18 hours, concentrate in vacuo to give a residue. Dissolve the residue in dimethylformamide and cool in an ice/water bath. Add methyl iodide (8.0 mL, 130 mmol). Warm slowly to ambient temperature. After 3.5 hours, pour the reaction mixture into water and extract twice with ether. Dry the combined organic layers over MgSO4 filter, and concentrate in vacuo to give the title compound: Rf =0.52 (silica gel, 2/1 hexane/ethyl acetate).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05519048 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-a6bd7bc6093740ba97ec9eedac026529 |
| 출처 메모 | uspto-grants-1996_05 |