Sodium Iodide → Tert-butyl 2-iodoacetate

HRID 440632

반응식

HRID 440632 반응식
Cl[CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[I-:10].[Na+]>CC(C)=O>[I:10][CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 66052tert-Butyl chloroacetate

생성물 1

HCID 11021060Tert-butyl 2-iodoacetate수율 77.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of t-butyl chloroacetate (20 g) and sodium iodide (25 g) is stirred in acetone (200 ml) for twenty hours. The acetone is removed by distillation under reduced pressure. The residue is partitioned between diethyl ether (100 ml) and water (50 ml). The ether layer is washed with water, 5% sodium thiosulfate solution, and water. The organic layer is dried over sodium sulfate, and evaporated under reduced pressure. There is obtained 25 grams of t-butyl iodoacetate. NMR: 63.5, 1.38.

후처리

  1. customThe acetone is removed by distillation under reduced pressure
  2. customThe residue is partitioned between diethyl ether (100 ml) and water (50 ml)
  3. washThe ether layer is washed with water, 5% sodium thiosulfate solution, and water
  4. dry with materialThe organic layer is dried over sodium sulfate
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3fe4f992b9eb42fb843d2e30f01bb3f4
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521103

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