Methallyl alcohol → 4-Chloro-2-(2-methyl-2-propen-1-yloxy)nitrobenzene

HRID 440651

반응식

HRID 440651 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([OH:8])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:18][C:19](=[CH2:22])[CH2:20]O>CC(=O)CC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([O:8][CH2:20][C:19]([CH3:22])=[CH2:18])[CH:7]=1

참가 물질

5

반응물 3

HCID 10557Methallyl alcoholHCID 11430Potassium CarbonateHCID 11900Phenol, 5-chloro-2-nitro-

생성물 1

HCID 224048134-Chloro-2-(2-methyl-2-propen-1-yloxy)nitrobenzene수율 84%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

반응 조건

온도
80 °C

실험 절차

A mixture of 30.0 g (0.17 mole) of 5-chloro-2-nitrophenol, 30.49 g (0.221 mole) of potassium carbonate, and 18.47 g (0.204 mole) of 2-methyl-2-propen-1-ol in 200 mL of 2-butanone was heated at 80° C. for approximately 16 hours. During this period the reaction changed color from orange to pale yellow. At the conclusion of this period the reaction mixture was filtered, and the filtrate was evaporated under reduced pressure, leaving 32.50 g of 4-chloro-2-(2-methyl-2-propen-1-yloxy)nitrobenzene as a solid residue, m.p. 47°-49° C.

후처리

  1. waitDuring this period the reaction changed
  2. filtrationAt the conclusion of this period the reaction mixture was filtered
  3. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-d371590700f54983b1d7d2d0dc81456b
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521147

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