N,N-Dimethyl-1,4-dioxaspiro[4.5]decan-8-amine → 4-(Dimethylamino)cyclohexan-1-one

HRID 440940노트

반응식

HRID 440940 반응식
C1O[C:4]2([CH2:9][CH2:8][CH:7]([N:10]([CH3:12])[CH3:11])[CH2:6][CH2:5]2)[O:3]C1>C(O)=O>[CH3:11][N:10]([CH3:12])[CH:7]1[CH2:8][CH2:9][C:4](=[O:3])[CH2:5][CH2:6]1

참가 물질

3

반응물 1

HCID 361167N,N-Dimethyl-1,4-dioxaspiro[4.5]decan-8-amine

생성물 1

HCID 103745454-(Dimethylamino)cyclohexan-1-one수율 100%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

4.96 gm (26.8 mMol) 4-dimethylamino-1-cyclohexanone ethylene ketal were dissolved in 50 mL formic acid and the solution stirred at reflux for 18 hours. The reaction mixture was then cooled to ambient and the volatiles removed under reduced pressure to give 3.78 gm (100%) of the title compound.

후처리

  1. temperatureat reflux for 18 hours
  2. temperatureThe reaction mixture was then cooled to ambient and the volatiles
  3. customremoved under reduced pressure

출처 및 근거

ORD 기록
ord-4dfc16dcbb2d4c73aea7b56866696ba8
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521197

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