Ethanolamine → 2-(1,3-Benzoxazol-2-ylamino)ethanol
반응식
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[CH2:11]([CH2:13][NH2:14])[OH:12]>O1CCCC1>[O:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[NH:14][CH2:13][CH2:11][OH:12]참가 물질
4
실험 절차
A solution of 2-chlorobenzoxazole (12.78 g) in dry tetrahydrofuran (50 ml) was added, over 10 minutes, to a stirred, ice-cooled solution of ethanolamine (15.3 g) in dry tetrahydrofuran (400 ml). The mixture was heated at reflux overnight, cooled, and the solvent evaporated. The residue was partitioned between water (500 ml) and dichloromethane (500 ml), and the resulting white solid filtered off, washed with dichloromethane and dried in vacuo to afford the title compound m.p. 162°-4° C.
후처리
- temperatureThe mixture was heated
- temperatureat reflux overnight
- temperaturecooled
- customthe solvent evaporated
- customThe residue was partitioned between water (500 ml) and dichloromethane (500 ml)
- filtrationthe resulting white solid filtered off
- washwashed with dichloromethane
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-efbc21db57d24d84affd0a2ac0a712d2
- 출처 데이터셋
- uspto-grants-1996_05
- 특허 번호
- US05521201
반응 노트
불러오는 중…