Methanol → 7-Isopropoxy-5-methoxy-2-methylsulfinylchromone

HRID 441060노트

반응식

HRID 441060 반응식
OO[S:3]([O-:5])=O.[K+].[CH:7]([O:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15](=S)[CH:16]=[C:17](C)[O:18]2)=[C:13]([O:23][CH3:24])[CH:12]=1)([CH3:9])[CH3:8].[OH2:25].[CH3:26]O>>[CH:7]([O:10][C:11]1[CH:20]=[C:19]2[C:14]([C:15](=[O:25])[CH:16]=[C:17]([S:3]([CH3:26])=[O:5])[O:18]2)=[C:13]([O:23][CH3:24])[CH:12]=1)([CH3:9])[CH3:8]

참가 물질

5

반응물 4

HCID 887MethanolHCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 570102217-Isopropoxy-5-methoxy-2-methylthiochromone

생성물 1

HCID 229064677-Isopropoxy-5-methoxy-2-methylsulfinylchromone

실험 절차

2 ml aqueous solution of 347 mg oxone (0.564 mmol) was added dropwise to 4 ml of 158 mg of 7-isopropoxy-5-methoxy-2-methylthiochromone (0.564 mmol) in methanol, and the mixture was stirred for 30 min. After addition of water, the reaction solution was extracted twice with ethyl acetate, and the organic layer washed with saturated NaCl water and dried over sodium sulfate anhydride. The solvent was then distilled off under reduced pressure, thus giving 147 mg of 7-isopropoxy-5-methoxy-2-methylsulfinylchromone (containing a little sulfone). This product was subjected without purification to the following reaction.

후처리

  1. extractionthe reaction solution was extracted twice with ethyl acetate
  2. washthe organic layer washed with saturated NaCl water
  3. dry with materialdried over sodium sulfate anhydride
  4. distillationThe solvent was then distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-ed02e5a589b74be5a271bdb0ca9296ed
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521216

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